Dibucaine Hydrochloride

99% Purity USP/EP/JP Standard Dibucaine Hydrochloride Powder

Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia. It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.

Details:

 

Product name: Dibucaine hydrochloride
Alias: Cinchocaine hydrochloride; 2-butoxy-n- (2- (diethylamino) ethyl) -4-quinolinecarboxamidmonohydrochlorid; 2-butoxy-n- (2- (diethylamino) ethyl) -cinchoninamidmonohydrochloride; 2-butoxy-n- (2 -diethylaminoethyl) cinchoninicacidamidehydrochloride; 2-n-butoxy-n- (2-diethylaminoethyl) cinchoninamidehydrochloride; 4-Quinolinecarboxamide, 2-butoxy-N- [2- (diethylamino) ethyl] -, monohydrochloride; Benzolin (localanesthetic); Butoxycinchoninicaciddiethylethylenediamidehydrochloride; C3225; 2 – {[(2-butoxyquinolin-4-yl) carbonyl] amino} -N, N-diethylethanaminium chloride; 2-butoxy-N- [2- (diethylamino) ethyl] quinoline-4-carboxamide dihydrochloride; Dibucaine HCl; Cinchocaine HCl
CAS: 61-12-1
EINECS number: 200-498-1
Molecular formula: C20H31Cl2N3O2
Molecular weight: 416.385
MP: 99-101 º C
Boiling point: 544.7 ° C at 760 mmHg
Flash Point: 283.2 ° C
Vapor Pressure: 3.37E-12mmHg at 25 ° C
Properties:
MP 99-101 ° C

Assay:99%

Standard:USP/EP/JP
Product use: Used as a local anesthetic

 

Description:

 

Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia. It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.

 

Dibucaine hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane’s permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
In combination sodium dibucaine hydrochloride is administered to dogs to induce rapid, humane, painless euthanasia. The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial, incineration or other method in compliance with state and local laws. 2,3

 

Dibucaine Hydrochloride  Applications:

 
Spinal anesthesia (high, low, saddle block) and topically to produce surface anesthesia. Eye: To anesthetize conjunctiva and cornea prior to superficial procedures (including tonometry, gonioscopy, removal of foreign bodies or sutures, corneal scraping).

 

Medical Use:

 
Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.

 

 

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