L-Triiodothyronine (T3)
L-Triiodothyronine (T3)

99% Purity L-Triiodothyronine (T3) Powder

Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.

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Details:

 

Sodium L-Triiodothyronine(T3)
CAS No: 55-06-1
Chemical name: 3, 3′, 5-Triiodo-L-thyronine, sodium salt, Oral use Flake T3
Molecular formula: C15H12I3NO4
Molecular Weight: 650.97
Content: (%): 99
Boiling point: 205° C
Water-solubility: 4 M NH4OH in methanol: 125 g/5mL,
Appearance: White or light yellow powder
Usage: Pharmaceutical intermediates, mix it with PEG 400 and take it orally.

 

COA:

 

Item Specification Result
Appearance An odorless, almost white or buff colored powder pass
Solubility 1,Very slightly soluble in water pass
2,slightly soluble in alcohol pass
3,practically insoluble in most other organic solvents pass
4,disolves in diluted aqueous sodium hydroxide solutions Pass
Identification a) Heat about 50 mg with a few drops of sulfuric acid in a porcelain crucible: violet vapors of iodine are evolved. pass
b)The retention time of the major peak is confirm to the RS pass
Loss on Drying Not more than 4.0% 0.46%
[a]20/DC=1 in 1M HCl/EtOH 1:4 +18 ~ +22o +20.9o
Assay(HPLC) Not less than 95.0% 99.18%
Levothyroxine sodium Not more than 5.0% 0.68%
Conclusion: Up to the Standard for Export

 

 

Description:

 

Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.

 

Production of T3 and its prohormone thyroxine (T4) is activated by thyroid-stimulating hormone (TSH), which is released from the pituitary gland. This pathway is regulated via a closed-loop feedback process: Elevated concentrations of T3, and T4 in the blood plasma inhibit the production of TSH in the pituitary gland. As concentrations of these hormones decrease, the pituitary gland increases production of TSH, and by these processes, a feedback control system is set up to regulate the amount of thyroid hormones that are in the bloodstream.

 

As the true hormone, the effects of T3 on target tissues are roughly four times more potent than those of T4. Of the thyroid hormone that is produced, just about 20% is T3, whereas 80% is produced as T4. Roughly 85% of the circulating T3 is later formed in the thyroid by removal of the iodine atom from the carbon atom number five of the outer ring of T4. In any case, the concentration of T3 in the human blood plasma is about one-fortieth that of T4. This is observed in fact because of the short half-life of T3, which is only 2.5 days. This compares with the half-life of T4, which is about 6.5 days.

 

Application
It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate. T3 increases the basal metabolic rate and, thus, increases the body’s oxygen and energy consumption. The basal metabolic rate is the minimal caloric requirement needed to sustain life in a resting individual.

T3 acts on the majority of tissues within the body, with a few exceptions including the spleen and testis. It increases the production of the Na+/K+ -ATPase and, in general, increases the turnover of different endogenous macromolecules by increasing their synthesis and degradation.

 

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